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CSN6-overexpression increases the expression of MMP2 and MMP9, but decreases the expression of p53, compared with CUL4A-knockdown alone. (A) The expression of MMP2 and MMP9 was measured using western blot analysis. (B) Western blotting was used to examine the expression of p53.*P<0.05 and **P<0.01 vs. shRNA-CUL4A-1 + pcDNA-NC. CSN6, COP9 signalosome subunit 6; MMP, matrix metallopeptidase; CUL4A, cullin 4A; shRNA, short hairpin RNA; NC, negative control.
