Table I.
Association between HIF-1 and non-coding RNA.
| Non-coding RNA | Category | Relationship with HIF-1 | Cancer type | (Refs.) |
|---|---|---|---|---|
| miR-124 | miRNA | Inhibits STAT3/HIF-1α pathway | Breast cancer | (39) |
| miR-200b | miRNA | Inhibits KLF2 gene and stabilizes HIF-1α signal | Human endothelial cells | (40) |
| miR-200c | miRNA | Inhibits HIF-1α expression | Lung cancer | (41) |
| miR-18a | miRNA | Inhibits HIF-1α expression | Breast cancer | (43) |
| miR-18a-5p | miRNA | Inhibits HIF-1α expression | Lung cancer | (42) |
| miR-302 | miRNA | Regulated by HIF-1α | HeLa cells | (44) |
| miR-210 | miRNA | Regulated by HIF-1α | Glioma; pancreatic cancer; colorectal cancer | (45–47) |
| miR-21 | miRNA | Activates PTEN/Akt/HIF-1α pathway; positive correlation with HIF-1α; targets FIH | Hepatocellular carcinoma; breast cancer; colon cancer; glioma | (46,48–50) |
| miR-126 | miRNA | Negative correlation with HIF-1α | Colon cancer | (46) |
| miR-130b | miRNA | Activates PTEN/Akt/HIF-1α pathway | Hepatocellular carcinoma | (50) |
| miR-1275 | miRNA | Regulated by HIF-1α and activates Notch and β-catenin pathway | Lung adenocarcinoma | (51) |
| miR-421 | miRNA | Upregulated by HIF-1α | Gastric cancer | (52) |
| miR-107 | miRNA | Targets HIF-1β | Ewing sarcoma | (53) |
| miR99a | miRNA | Inhibits mTOR/HIF-1α signal pathway | Breast cancer | (54) |
| miR-31 | miRNA | Targets the 3′ untranslated region of FIH transcript | Head and neck squamous cell carcinoma; oral squamous cell carcinoma; colorectal cancer; lung cancer | (55–58) |
| miR-31-5p | miRNA | Targets the 3′ untranslated region of FIH transcript | Lung cancer | (59) |
| miR-184 | miRNA | Targets FIH | head and neck squamous cell carcinoma | (60) |
| LOC554202 | lncRNA | Positively correlated with miR-31 | Lung cancer | (58) |
| LINC00996 | lncRNA | Regulates HIF-1α signal | Colorectal cancer | (63) |
| LincRNA-p21 | lncRNA | Regulated by HIF-1α and induces HIF-1α accumulation | HeLa cells | (64,65) |
| LncHIFCAR/ MIR31HG | lncRNA | Promotes the binding of HIF-1α to target genes | Oral cancer | (66) |
| PCGEM1 | lncRNA | Forms a complex with HIF-1α and SNAI1 | Gastric cancer | (67) |
| CRPAT4 | lncRNA | Regulated by HIF-1α | Clear cell renal cell carcinoma | (68) |
| TUG1 | lncRNA | Protects HIF-1α mRNA 3′ untranslated region from miR-143-5p | Osteosarcoma | (71) |
| miR31HG | lncRNA | Serves as a HIF-1α co-activator | Oral cancer | (66,72,73) |
| NEAT1 | lncRNA | Induced by HIF-1α and regulates the expression of UCK2 gene through suppressing miR-199a-3p | Hepatocellular carcinoma | (76) |
HIF-1, hypoxia inducible factor-1; miR/miRNA, microRNA; lncRNA, long non-coding RNA; KLF2, Krüppel-like factor 2; PTEN, phosphatase and tensin homolog; SNAI1, Snail homolog 1; FIH, factor inhibiting HIF-1; UCK2, uridine-cytidine kinase 2.