Table II.

Association between HIF-1 and signaling pathways.

Signaling pathway	Relationship with HIF-1	Cancer type	(Refs.)
PI3K/Akt/mTOR	Maintains the transcription, translation and biological activity of HIF-1α; activated by HIF-1α-dependent tuftelin1; regulated by HIF-1α; involved in regulating the formation of HIF-1α/p300 complex	Breast cancer; hepatocellular carcinoma; prostate cancer; pancreatic cancer	(50,54,124,125,146)
Wnt/β-catenin	Activates the transcription of HIF-1α; also activated by HIF-1α	Hepatocellular carcinoma; esophageal squamous cell carcinoma	(50,127)
Hippo	Regulated by HIF-1α; TAZ recruits HIF-1α to promote CTGF expression	Breast cancer	(6,7,86,128)
Notch	Regulated by HIF-1α	Leukemia; glioblastoma; ovarian cancer	(50,81,86)
JAK/STAT	Activated by HIF-1α	Glioma	(81,134)
SNAI1	Regulated by HIF-1α	Hepatocellular carcinoma	(50,135)
Snail	Activated by HIF-1α	Gastric cancer; ovarian cancer	(136,137)
MAPK	Regulated by DUSPs in a HIF-1-dependent manner under chemotherapy conditions; involved in regulating the formation of HIF-1α/p300 complex	Breast cancer; clear-cell renal cell carcinoma	(138,144)
Sonic Hedgehog	Activated by hypoxia in a HIF-1-dependent way	Cholangiocarcinoma; prostate cancer	(149,140)
NF-κB	Activated by HIF-1α; also activated by hypoxia-related factors to switch HIF-1α to HIF-2α; competes for the binding of p300 to the promoter of HRE-encoding genes	Bladder cancer; ovarian cancer	(141–143)
PI3K/PKB pathway	Promotes the binding of HIF-1α/phosphorylated p300 to GK-HRE	Hepatocytes	(145)
pSTAT3/HIF-1α/VEGF pathway	Promotes the occurrence of. immunosuppression	Glioblastoma multiforme	(104–106)

HIF-1, hypoxia inducible factor-1; TAZ, tafazzin; CTGF, connective tissue growth factor; DUSPs, dual-specificity phosphatases; VEGF, vascular endothelial growth factor; SNAI1, Snail homolog 1; GK, glucokinase; HRE, hypoxic response element; p, phosphorylated.