Table IV.

Potential therapeutic targets associated with HIF-1.

Potential targets	Possible mechanism	(Refs.)
MAT2A	Maintains the demethylation status of genes	(28)
SENP1	Serves as a SUMO protease and forms a positive feedback loop with HIF-1α	(31,32)
ERK	Phosphorylates HIF-1α and increases its expression and stability	(25,33)
PKA	Prevents HIF-1α degradation	(34)
YB-1	Participates in regulating HIF-1 phosphorylation	(35,36)
Indoleamine 2,3-dioxygenase	Breaks down tryptophan and regulates tumor immunity	(107)
Carbonic anhydrase	Regulates intracellular PH	(119,120)

HIF-1, hypoxia inducible factor-1; MAT2A, methionine adenosyltransferase 2A; SENP1, small ubiquitin-like modifier proteases 1; PKA, protein kinase A; YB-1, Y-box binding protein 1; SUMO, small ubiquitin-like modifier.