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Basic structure of laminin and the endothelial cell basement membrane (EC-BM). (A) Molecular structure of EC-BM. The laminin network anchors to ECs by interacting with integrins, a-dystroglycan, and sulfated glycolipids. Lateral interactions are made with agrin and perlecan. The laminin network links to an independent type IV collagen network via nidogen and HS. (B) Lm511 and Lm411 heterotrimers. Domain locations for laminin-binding to nidogen and cellular receptors are indicated.
