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. 2020 Oct 29;11:574839. doi: 10.3389/fimmu.2020.574839

Figure 4.

Figure 4

The therapeutic effect of in vitro-generated myeloid-derived suppressor cells (MDSCs) in APAP-induced liver injury. (A) The experiment scheme of in vitro-generated MDSCs. (B) The suppressive abilities of MDSCs. These in vitro-generated MDSCs (8 x 106 cells) were adoptively transferred into mice just after APAP challenge to evaluate the survival (C) and the fold change of ALT level at 12 h after APAP injection (D), n=12-16 per group. Log-rank test and Kruskal-Wallis test are used to analyze survival curve and the fold change of ALT level respectively. *P < 0.05, **P < 0.01, ***P < 0.001. (E) The ALT level of the post-treatment of TNF-α/LPS MDSC or NAC at 12 h after APAP injection. At 2 h after APAP injection, TNF-α/LPS MDSCs were adoptively transferred into mice, and NAC was intraperitoneally injected into mice respectively, n=15-20 per group. *P < 0.05, **P < 0.01, NS, no significance, Kruskal-Wallis test. (F) The survival of the post-treatment of TNF-α/LPS MDSC and NAC (n=15-20 per group). *P < 0.05, **P < 0.01, ***P < 0.001, NS, no significance, Log-rank test. Data were expressed as mean ± SD.