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Promoter clearence carried out by the RSC complex. (A) RSC complexes act creating a nucleosome depleted region (NDR) around the TSS shifting the +1 nucleosome position, making this regions more accesible for different factors as TBP (TATA binding protein) thereby promoting transcription initiation. (B) Upon RSC depletion, NDRs around TSS are not formed and this impairs TBP binding and transcription initiation.
