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Role of ARID1A in compartments and TADs establishment. (A) In ovarian cancer cell lines ARID1A is present at enhancers and promoters co-localizing with the condensin subunit NCAPH2 (that recognizes and binds to H3K27ac marked enhancers). (B) Upon ARID1A depletion, NCAPH2 relocalizes to a subset of promoters. CAPH2 re-localization induces the gene expression of these promoter targets, whether this activity is responsible for B to A compartment switching is still unclear.
