Table 1.

Reconstructed GEM examples of priority pathogens reported by World Health Organization (2017).

Pathogen	Priority	Model name	Number of metabolites	Number of genes	Number of reactions	References
Mycobacterium tuberculosis	Global	iNJ661	826	661	1,025	Jamshidi and Palsson, 2007
		GSMN-TB	645	726	856	Beste et al., 2007
		GSMN-TB 1.1	766	759	876	Lofthouse et al., 2013
		sMtb	929	915	1,192	Rienksma et al., 2014
		iOSDD890	961	890	1,152	Vashisht et al., 2014
		iSM810	723	810	938	Ma et al., 2015
		iEK1011	998	1011	1,128	Kavvas et al., 2018
Acinetobacter baumannii	Critical	AbyMBEL891	778	650	891	Kim et al., 2010
		iLP844	1,509	844	1,628	Presta et al., 2017
		iCN718	890	718	1,016	Norsigian et al., 2018
Pseudomonas aeruginosa	Critical	iMO1056	760	1,056	883	Oberhardt et al., 2008
		iMO1086	1,021	1,086	1,031	Oberhardt et al., 2011
		iPae1146	1,284	1146	1,493	Bartell et al., 2017
		iPau1129	1,286	1,129	1,495	Bartell et al., 2017
		iPAO1	3,022	1,458	4,265	Zhu et al., 2018
Escherichia coli	Critical	15 pathogenic strain	1,378–1,484	4,584–5,784	1,473–1,564	Vieira et al., 2011
Klebsiella pneumoniae	Critical	iYL1228	1,685	1,228	1,970	Liao et al., 2011
Helicobacter pylori	High	iCS291	403	291	388	Schilling et al., 2002
		iIT341	485	341	554	Thiele et al., 2005
Salmonella typhimurium	High	iRR1083	774	1,083	1,087	Raghunathan et al., 2009
		iMA945	1,036	945	1,964	AbuOun et al., 2009
		STM_v1.0	1,119	1,270	2,201	Thiele et al., 2011
		MetaSal	1,088	824	1„097	Hartman et al., 2014
Staphylococcus aureus	High	iSB619	571	619	641	Becker and Palsson, 2005
		iMH551	604	551	712	Heinemann et al., 2005
		iSA863	1,379	863	1,545	Mazharul Islam et al., 2020
Campylobacter jejuni	High	-	467	388	536	Metris et al., 2011
Streptococcus pneumoniae	Medium	iDS372	355	372	462	Dias et al., 2019
Haemophilus influenzae	Medium	iJE296	343	296	488	Edwards and Palsson, 1999
		iCS400	451	400	561	Schilling and Palsson, 2000