Table 3.

Univariate and multivariate analyses of different clinical characteristics in TCGA and ICGC cohorts.

TCGA cohort	Univariate Cox analysis			Multivariate Cox regression
	HR	95%CI	P-value	HR	95%CI	P-value
Age	1.005	0.990–1.020	0.50645	1.01	0.994–1.026	0.198323
Gender	0.807	0.542–1.203	0.293326	0.896	0.590–1.361	0.608359
Histological grade	1.111	0.854–1.446	0.43213	0.998	0.749–1.328	0.988103
TNM stage	1.804	1.456–2.234	<0.001	1.687	1.345–2.117	<0.001
Risk score	1.61	1.442–1.798	<0.001	1.591	1.411–1.794	<0.001
ICGC cohort	Univariate Cox analysis			Multivariate Cox regression
	HR	95%CI	P-value	HR	95%CI	P-value
Age	1	0.969–1.032	0.987595	1	0.965–1.035	0.990104
Gender	0.454	0.240–0.860	0.015353	0.432	0.221–0.846	0.014352
Histological grade	NA	NA	NA	NA	NA	NA
TNM stage	2.12	1.448–3.104	<0.001	1.927	1.344–2.764	<0.001
Risk score	1.542	1.310–1.815	<0.001	1.421	1.185–1.705	<0.001

HR, hazard ratio; CI, confidence interval; NA, not available.