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. 2020 Oct 29;11:563044. doi: 10.3389/fimmu.2020.563044

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Copyright © 2020 Xie, Zhang, Shi, Liu, Hu, Qie, Chen, Wang, Wang, Jiang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VISTA expression pattern in human breast cancer tissue. (A) Representative immunohistochemical staining for the VISTA protein in normal breast tissue (n=4), breast adenosis tissue (n=2), paracancerous tissue (n=13) and breast cancer tissue (n=324). Original magnification, 400 ×. (B) The expression of VISTA in breast cancer detected by immunohistochemistry. VISTA negative (n=186, 57.41%) vs. VISTA positive (n=138, 42.59%). (C) Representative positive VISTA staining in immune cells (110/324, 33.95%), tumor cells (47/324, 14.51%), and both types of cells (19/324, 5.86%). Original magnification, 200 ×.