Table 1.
Summary of main findings in the included studies.
| Author | Year | Type of cerebral oximeter | Type of CA | Clinical setting | Conclusion | Reference |
|---|---|---|---|---|---|---|
| EARLIER DETECTION OF RE-ARREST | ||||||
| Frisch | 2012 | InSpectra | OHCA | Prehospital | A decline in rSO2 level may correlate with re-arrest. | (24) |
| Meex | 2013 | FORE-SIGHT | OHCA | Re-arrest was accompanied with sudden drop in rSO2 | (55) | |
| Schewe | 2014 | EQANOX 7600 | OHCA | Prehospital-VT | rSO2 decreased prior to re-arrest. | (56) |
| Nomura | 2016 | HAND ai TOS | OHCA | Prehospital-PEA | Re-arrest PEA was accompanied with sudden drop in rSO2 | (57) |
| ASSESSMENT OF CPR QUALITY | ||||||
| Paarmann | 2010 | INVOX 5100 | IHCA | In-hospital | rSO2 may be a non-invasive alternative for the assessment of the adequacy of oxygen transport (i.e. CPR efforts). | (58) |
| Kämäräinen | 2012 | INVOS 5100c | IHCA | In-hospital | High quality CPR and improving CPR technique was not significantly reflected in rSO2 as quantified. | (59) |
| Meex | 2013 | FORE-SIGHT/EQUANOX advance | IHCA/OHCA | In-hospital | Decrease in rSO2 during interruption of CPR Increase in rSO2 due to improved resuscitation efforts | (55) |
| Schewe | 2014 | Equanox 7600 | OHCA | Prehospital (mechanical CPR) | rSO2 during mechanical CPR was higher compared to manual compression | (56) |
| Parnia | 2014 | Equanox 7600 | IHCA | In-hospital (mechanical CPR) | Mechanical CPR was significantly associated with higher rSO2 compared with manual chest compression. | (60) |
| Ogawa | 2015 | TOS-OR | OHCA | ER (mechanical CPR) | LDB-CPR significantly increased rSO2 value compared with manual CPR. | (61) |
| PREDICTION OF ROSC | ||||||
| Asim | 2014 | INVOS 5100c | OHCA | ER | ROSC was established in the patients with rise in rSO2. | (62) |
| Sanfilippo | 2015 | N/A | IHCA/OHCA | Both initial and average rSO2 values were significantly higher in the ROSC group than in the non-ROSC group. | (63) | |
| Cournoyer | 2016 | N/A | IHCA/OHCA | Mean NIRS value were higher in patients experiencing ROSC than in their respective counterparts. | (53) | |
| Schnaubelt | 2018 | N/A | IHCA/OHCA | Both mean rSO2 and ΔrSO2 were higher in the ROSC group than in the non-ROSC group. | (64) | |
| Takegawa | 2019 | TOS-OR | OHCA | ER | The combination of baseline rSO2 with the amount of maximum rise in rSO2 over time is better predictor of ROSC. | (65) |
| PREDICTION OF FAVORABLE NEUROLOGICAL OUTCOMES | ||||||
| Meex | 2013 | FORE-SIGHT | OHCA | ICU-During TTM | rSO2 value was significantly lower in non-survivors compared with survivors at 3 h after induction of TTM. | (66) |
| Storm | 2014 | INVOS 5100c | IHCA/OHCA | ICU-During TTM | rSO2 within the first 40 h after ROSC is significantly lower in patients with poor neurological outcome. | (67) |
| Genbrugge | 2016 | FORE-SIGHT | OHCA | ICU-During TTM | The mean rSO2 in the rewarming phase was significantly higher among patients with CPC scores of 1–2. | (68) |
| Cournoyer | 2016 | N/A | IHCA/OHCA | Mean NIRS value or combined initial and mean NIRS values were higher in patients with good neurologic outcomes. | (53) | |
| Bougle | 2016 | INVOS | OHCA | ICU-During TTM | rSO2 within 48 h after ICU admission does not allow discriminating patients with good or bad outcome. | (69) |
| Schnaubelt | 2018 | N/A | IHCA/OHCA | ROC analysis could not confirm a significant discriminatory power for mean rSO2 values. | (64) | |
| Saritas | 2018 | INVOS | CA | ICU-During TTM | There was no significant correlation between rSO2 values and neurologic outcomes. | (70) |
| Nakatani | 2018 | INVOS 5100c | OHCA | ER/ICU-During TTM | TTM at 32–34°C effectively decreased all-cause mortality in comatose OHCA patients with rSO2 41–60% on arrival. | (71) |
| Jakkula | 2019 | INVOS 5100c | OHCA | ICU | No association between rSO2 and NSE at 24, 48, 72 h after OHCA or good neurological outcomes at 6 months. | (72) |
| Sakurai | 2020 | INVOS 5100c | OHCA | ICU- During TTM | There was no significant difference in rSO2 values between prognosis groups at any time point. | (73) |
CA, Cardiac arrest; OHCA, Out-of-hospital cardiac arrest; IHCA, in-hospital cardiac arrest; rSO2, regional cerebral oxygen saturation; ROSC, return of spontaneous circulation; CPR, cardiopulmonary resuscitation; CPC, cerebral performance category; ER, emergency room; ICU, intensive care unit; LDB, load distributing band; NSE, neuron specific enolase; ROC, receiver operating characteristic; TTM, targeted temperature management; N/A, not available.