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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Endocrinol. 2020 Dec;247(3):213–224. doi: 10.1530/JOE-20-0275

Figure 1: Fasted male FVB:P129 mice showed decreased body weight, blood glucose and leptin with 24 (red) and 48 (blue) hour fast. Serum GH in males had a biphasic response to the 24 and 48 h fast, and increased ghrelin with the 48 hr fast. Female fasted FVB:P129 mice had decreased body weight, blood glucose and leptin, while having increased serum GH with the 24 h (purple) fast.

Figure 1:

(a) the difference in body weight (b) blood glucose, (c) serum leptin, (d) serum GH and (e) serum ghrelin were measured relative to ad libitum fed controls (Fed). Addition of 10% glucose to drinking water resulted in partial reversal of fasting effects with 24 and 48 h (Fasted +Glucose). All sets; n = 5–8 per condition; error bars are SEM. Values that differ significantly among time points within a treatment condition: *P<0.05; **P<0.01, ***P<0.001, ****P<0.0001. Values that differ significantly (P < 0.05) with the same time point among different treatment conditions: “a” significant with fed group, “b” significant with fasted group, and “c” significant with fasted+glucose group. Two-way ANOVA (males) and one-way ANOVA (females).