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. 2020 Jun 22;30(11):5930–5942. doi: 10.1093/cercor/bhaa167

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Published by Oxford University Press 2020.

This work is written by US Government employees and is in the public domain in the US.

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(a) Principal component analysis of CANTAB executive function tasks. The top two principal components had strong loadings for SWM processes (PC1; spatial cognition) and simple reaction time (PC2; response time). (b) Mediation analyses. Sensorimotor network segregation significantly mediated the relationship between age and spatial cognition performance (top). Sensorimotor network glucose metabolism significantly mediated the relationship between age and response time (bottom). In both analyses, when accounting for the mediation effects, the direct effects of age on spatial cognition and response time were no longer significant.