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. 2020 Nov 18;15(11):e0242092. doi: 10.1371/journal.pone.0242092

Fig 2. The correlation between the percentage of M-MDSC and proinflammatory T cells.

Fig 2

(A) The frequency of CD4+IL-17+ Th17 cells and CD4+ IFN-γ+ T cells in PBMC was increased in T1D patients (n = 55) and their at-risk relatives (n = 21) compared to healthy donors (HD) (n = 24). *p≤0.05, **p≤0.01, ***p≤0.001 (Mann-Whitney test). (B) The frequency of CD4+IL-17+ Th17 cells was in a strong correlation with the frequency of M-MDSC from PBMC in T1D patients and at-risk relatives. No correlation was found between the frequency of M-MDSC and Th17 cells in HD. Each point represents the value from an individual subject. The r value indicates the correlation index according to Spearman correlation analysis. (C) The frequency of CD4+ IFN-γ+ T cells positively correlates with the frequency of M-MDSC from PBMC in T1D patients and their at-risk relatives. In contrast, a moderate negative correlation was found between the frequency of M-MDSCs and CD4+ IFN-γ+ T cells in HD. For correlation analyses, each point represents the value from an individual subject. The r values indicate the correlation index according to Spearman correlation analysis.