Fig. 2.

Core set of overlapping phenotypes from preclinical Fmr1 and Cyfip1 deletion models. Rodent models of Fmr1 deletion (Fmr1−/y, whereby the single X-linked copy of Fmr1 is deleted in males) or heterozygous Cyfip1 deletion (Cyfip1+/−) mirror clinical populations with FXS and 15q11.2 CNV deletions, respectively. Moreover, these 2 rodent models share a core set of functionally related neurobiological phenotypes, including (i) altered spine and dendritic morphology, (ii) dysregulated protein translation and (iii) elevated long-term depression. Further work is required to fully delineate the consequences of Fmr1 and Cyfip1 deletion, and characterize the similarities. FXS, fragile X syndrome; CNV, copy number variant.