Table 1.
Polymorphisms related to BBB function as reported in the schizophrenia PGC database
| SNP | Gene | Function | Chromosome | A1 | A2 | OR | p value |
|---|---|---|---|---|---|---|---|
| rs10314 | CLDN5 | TJ | chr22 | C | G | 1.02 | 1.84E–01 |
| rs10791345 | JAM3 | TJ | chr11 | A | G | 0.95 | 4.10E–04 |
| rs55661361 | ESAM | TJ | chr11 | A | G | 0.92 | 3.68E–12 |
| rs989192 | GJA8 | GJ | chr1 | A | G | 1.01 | 4.85E–01 |
| rs4950495 | GJA8 | GJ | chr1 | T | C | 1.01 | 4.20E–01 |
| rs1045642 | ABCB1 | TPA | chr7 | A | G | 0.97 | 5.38E–03 |
| rs12814239 | LRP1 | TPA | chr12 | T | C | 0.86 | 1.48E–09 |
| rs324017 | LRP1 | TPA | chr12 | A | C | 0.94 | 2.13E–07 |
| rs11098403 | NDST3 | ECM | chr4 | A | G | 0.95 | 3.52E–05 |
| rs2445142 | HSPG2 | ECM | chr1 | C | G | 0.98 | 8.72E–02 |
Presented is a list of BBB gene polymorphisms that have been reported in smaller case-control studies, and those polymorphisms were cross-referenced with the findings described in the large schizophrenia PCG database. SNP, single-nucleotide polymorphism. Bold text indicates findings that are genome wide significant level.