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. 2020 Nov 4;6(45):eabb5924. doi: 10.1126/sciadv.abb5924

Fig. 6. 10074-G5 is effective in reducing functional impairment in a C. elegans model of Aβ42 toxicity.

Fig. 6

(A) Treatment profile used for the C. elegans experiments. (B) NIAD-4 staining of C. elegans aggregates in the presence and absence of 5 μM 10074-G5. (C) Quantification of NIAD-4 intensity shown in (B). n ≥ 9. (D) Health scores (%) for the rate of body bends, speed of movement, moving percent, and magnitude of body bends at day 6 of adulthood. The colors are the same as those shown in (C). Scores are normalized to the N2 control strain (gray). n = 150. (E) Combined total health scores [average of health scores in (D)]. In all panels, error bars represent ± SEM. P values were determined by two-tailed Student’s t test. 10074-G5 shows minimal movement effects on wild-type C. elegans (fig. S10).