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. 2020 Nov 11;6(46):eabd6764. doi: 10.1126/sciadv.abd6764

Fig. 1. miR-519c expression is down-regulated in pancreatic cancer, and its overexpression inhibits HIF-1α, Hh signaling, and cell migration under hypoxic condition.

Fig. 1

miR-519c was down-regulated in patient tissues (A) and pancreatic cancer cell lines (B), compared to paired normal tissues and normal pancreatic cells such as HPDE. Further, miR-519c inhibited the expression of HIF-1α and Hh ligands such as SHH, SMO, and GLI1 after the transfection of MIA PaCa-2R cells with Lipofectamine/miR-519c under hypoxic condition (C and D). (E) miR-519c also inhibited cell migration under hypoxic condition when MIA PaCa-2R cells were cultured on Transwell chamber with human pancreatic stellate cells (hPSCs). *P < 0.05, two-paired t test.