Figure 1. Cell-autonomous and non-autonomous effects of Pafah1b1 heterozygous loss on radial migration.

(A) Images of DAPI-stained hippocampus of WT, GlobalLis (global mutation), NkxLis (IN-specific mutation), and EmxLis (PC-specific mutation) mice. (B) Images of PV- immunostaining in WT, GlobalLis, NkxLis, and EmxLis CA1. Bottom images show higher magnification of top images. (C) Quantified densities of PV+INTs in CA1 and each sublayer. Counting was performed on four hippocampal sections from each animal (n = 5 animals per genotype). For statistical analysis *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. (D) Percentage of PV+INTs in deep (s.o./s.p.) or superficial (s.r./s.l.m.) layers. Scale bar A = 600 μm, scale bar B (top) = 200 μm, scale bar B (bottom) = 120 μm.