Table 1. Membrane, firing and morphological properties of PV+INTs.
Table 1—source data 1. Morphophysiological properties of PV+INTs.
elife-62373-table1-data1.xlsx (58KB, xlsx)
| WT FS 67 cells |
GlobalLis FS 20 cells |
NkxLis FS 12 cells |
EmxLis FS 30 cells |
WT IS 0 cells |
GlobalLis IS 21 cells |
NkxLis IS 21 cells |
EmxLis IS 0 cells |
WT NFS 16 cells |
GlobalLis NFS 4 cells |
NkxLis NFS 8 cells |
EmxLis NFS 8 cells |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Input resistance (MΩ) | 82.5 ± 3.6 | 63.5 ± 4.2 | 61.1 ± 6.3 | 75.0 ± 4.7 | N/a | 88.5 ± 4.9 | 85.5 ± 7.0 | N/a | 143.1 ± 11.9 | 132.0 ± 14.4 | 200.7 ± 17.0 | 173.2 ± 9.0 |
| Rheobase (pA) | 364.2 ± 17.3 | 457.5 ± 22.2 | 533.3 ± 42.3 | 463.3 ± 24.8 | n/a | 340.5 ± 20.0 | 342.9 ± 21.1 | n/a | 153.1 ± 14.8 | 162.5 ± 20.0 | 125.0 ± 13.4 | 143.8 ± 11.3 |
| Firing Freq 2x Threshold (Hz) | 137.6 ± 4.7 | 168.5 ± 11.2 | 173.2 ± 14.8 | 155.4 ± 7.4 | n/a | 106.2 ± 4.8 | 95.6 ± 3.5 | n/a | 66.0 ± 4.5 | 57.0 ± 11.6 | 72.3 ± 4.4 | 58.0 ± 3.5 |
| Adaptation Ratio 2x Threshold | 0.79 ± 0.02 | 0.80 ± 0.03 | 0.72 ± 0.04 | 0.71 ± 0.02 | n/a | 0.71 ± 0.03 | 0.65 ± 0.03 | n/a | 0.67 ± 0.03 | 0.79 ± 0.05 | 0.79 ± 0.06 | 0.52 ± 0.05 |
| Firing Freq 3x Threshold (Hz) | 170.9 ± 5.1 | 216.5 ± 11.5 | 213.0 ± 15.3 | 195.7 ± 10.3 | n/a | 130.2 ± 6.0 | 131.1 ± 5.1 | n/a | 96.1 ± 4.6 | 74.5 ± 15.1 | 100.8 ± 5.7 | 77.8 ± 6.9 |
| Adaptation Ratio 3x Threshold | 0.78 ± 0.01 | 0.82 ± 0.03 | 0.71 ± 0.05 | 0.71 ± 0.02 | n/a | 0.67 ± 0.02 | 0.57 ± 0.03 | n/a | 0.65 ± 0.03 | 0.64 ± 0.10 | 0.73 ± 0.05 | 0.47 ± 0.05 |
| AP Threshold (mV) | −39.9 ± 0.7 | −41.2 ± 1.2 | −39.9 ± 1.3 | −37.8 ± 1.1 | n/a | −40.4 ± 1.1 | −35.9 ± 1.2 | n/a | −40.6 ± 1.2 | −38.6 ± 2.8 | −36.8 ± 1.2 | −36.8 ± 1.3 |
| AP Half-width (ms) | 0.42 ± 0.01 | 0.34 ± 0.01 | 0.35 ± 0.01 | 0.36 ± 0.01 | n/a | 0.48 ± 0.01 | 0.44 ± 0.01 | n/a | 0.59 ± 0.02 | 0.64 ± 0.07 | 0.56 ± 0.04 | 0.58 ± 0.04 |
| AP Amplitude (mV) | 61.1 ± 1.0 | 61.2 ± 2.7 | 55.8 ± 3.0 | 57.5 ± 2.0 | n/a | 62.1 ± 2.3 | 53.6 ± 2.0 | n/a | 65.4 ± 3.2 | 64.8 ± 7.0 | 55.1 ± 5.7 | 64.9 ± 4.8 |
| AP Max Rise Slope (mV/ms) | 259.9 ± 5.2 | 248.3 ± 13.5 | 268.6 ± 11.7 | 217.0 ± 12.1 | n/a | 261.4 ± 10.7 | 231.0 ± 10.3 | n/a | 228.6 ± 11.5 | 210.3 ± 25.0 | 197.9 ± 18.3 | 241.0 ± 26.0 |
| AP Max Decay Slope (mV/ms) | −188.7 ± 5.5 | −176.0 ± 14.3 | −201.6 ± 9.1 | −211.4 ± 12.6 | n/a | −198.1 ± 12.6 | −149.2 ± 7.1 | n/a | −136.5 ± 11.5 | −131.3 ± 20.6 | −119.2 ± 14.7 | −125.4 ± 16.8 |
| AHP Amplitude (mV) | −16.8 ± 0.6 | −17.5 ± 0.9 | −15.3 ± 0.9 | −16.7 ± 0.7 | n/a | −16.3 ± 0.8 | −16.0 ± 1.0 | n/a | −15.7 ± 1.2 | −16.9 ± 1.1 | −17.0 ± 1.2 | −11.3 ± 1.7 |
| Membrane Time Constant (ms) | 8.5 ± 0.5 | 7.5 ± 0.4 | 6.7 ± 0.4 | 8.6 ± 0.4 | n/a | 8.7 ± 0.4 | 8.5 ± 0.7 | n/a | 10.9 ± 0.6 | 12.9 ± 0.6 | 14.8 ± 1.6 | 17.1 ± 1.0 |
| Membrane Capacitance (pF) | 104.4 ± 5.0 | 117.7 ± 6.6 | 116.8 ± 18.6 | 123.9 ± 7.7 | n/a | 103.7 ± 8.6 | 105.7 ± 8.3 | n/a | 91.3 ± 6.4 | 88.6 ± 6.4 | 73.8 ± 4.8 | 97.0 ± 4.3 |
| Sag Index | 0.90 ± 0.01 | 0.91 ± 0.01 | 0.95 ± 0.01 | 0.92 ± 0.01 | n/a | 0.90 ± 0.01 | 0.91 ± 0.01 | n/a | 0.8 ± 0.03 | 0.82 ± 0.04 | 0.86 ± 0.02 | 0.85 ± 0.02 |
| Total Sholl Intersections (Dendrite) | 48 ± 7 (19 cells) |
65 ± 6 (6 cells) |
43 ± 8 (8 cells) |
56 ± 7 (11 cells) |
n/a | 43 ± 7 (7 cells) |
61 ± 11 (8 cells) |
n/a | 26 ± 4 (10 cells) |
28 ± 8 (2 cells) |
34 ± 11 (3 cells) |
38 ± 10 (4 cells) |
| Total Sholl Intersections (Axon) |
222 ± 22 | 271 ± 44 | 206 ± 44 | 324 ± 51 | n/a | 224 ± 56 | 224 ± 41 | n/a | 131 ± 15 | 133 ± 3 | 97 ± 21 | 95 ± 26 |
| Postnatal age at time of recording (days) | 29 ± 1 | 26 ± 1 | 29 ± 1 | 29 ± 2 | n/a | 26 ± 1 | 27 ± 1 | n/a | 28 ± 1 | 25 ± 3 | 27 ± 1 | 28 ± 3 |