Table 3.

Multivariate analyses of association between various parameters and overall survival

		Univariate		Multivariate
		HR	p	HR	95% CI	p
Age	>65	Reference	0.0641
	≤65	1.539
Sex	Male	Reference	0.4369
	Female	1.257
Pathology	Non-clear	Reference	0.0035	Reference		0.0110
	Clear	0.432		0.477	0.269–0.844
KPS	≥80%	Reference	0.2527
	<80%	1.573
Anemia	(−)	Reference	0.0004	Reference		0.0658
	(+)	2.201		1.557	0.971–2.495
Hypercalcemia	(−)	Reference	<0.0001	Reference		0.0005
	(+)	10.315		5.233	2.074–13.203
Time from diagnosis to treatment	<1 year	Reference	0.0002	Reference		0.0072
	≥1 year	0.407		0.479	0.280–0.819
Liver metastasis	(+)	Reference	0.2816
	(−)	0.705
Bone metastasis	(+)	Reference	0.3267
	(−)	0.793
SII	≤730	Reference	<0.0001	Reference		0.0259
	>730	2.424		1.721	1.067–2.774

CI: confidence interval; HR: hazard ratio; KPS: Karnofsky Performance Status; SII: systemic immune inflammation index.