Table 1.
The approaches of PACAP38 administration in stroke.
| Year | Author | Animal | Model | Administration
|
|||
|---|---|---|---|---|---|---|---|
| Routes | Starting time | Duration | Best dosage | ||||
| 1996 | Uchida D. et.al.[15] | Rats | Transient global ischemia | i.c.v. i.v. |
Post-surgery Post-surgery and post-24h |
Continuous | 1pmol/h 16pmol/h and 160pmol/h |
| 1998 | Somogyvari-vigh A. et.al.[172] | Rats | Transient global ischemia | i.v. | Post-24h | Single with continuous | 5nmol/kg with 160pmol/h |
| 1998 | Shioda F. et.al.[43] | Rats | Transient global ischemia | i.c.v. | Pre-48h | Continuous | 1pmol/h |
| 2000 | Reglodi D. et.al.[98] | Rats | tMCAO | i.v. | Post-6h | Single with continuous | 20nmol/kg with 160pmol/h |
| 2000 | Reglodi D. et.al.[99] | Rats | tMCAO | i.v. | Post-4h, 8h, 12h | Single with continuous | 5nmol/rat with 160pmol/h |
| 2002 | Dohi K. et.al.[44] | Rats | tMCAO | i.c.v. | Pre-48h | Continuous | 1pmol/h |
| 2002 | Yan D. et.al.[114] | Rats | Transient global ischemia | i.c.v. | Pre-15min | Single | 10nmol/rat |
| 2002 | Tamas A. et.al.[96] | Rats | pMCAO | i.c.v. | Pre-surgery | Single | 450pmol/rat |
| 2002&2004 | Reglodi D. et.al.[157, 171] | Rats | pMCAO | i.c.v. | Pre-surgery | Single | 2μg/rat |
| 2006 | Chen Y. et.al.[97] | Mice | pMCAO | i.c.v. i.v. |
Post-1h | Single | 40pmol/mouse 0.75nmol/mouse |
| 2009 | Lenti L. et.al.[130] | Newborn pigs | CO2 ventilation induced transient global ischemia | Directive expose | Pre-CO2 ventilation | Continuous | 10pmol/L |
| 2010 | Stetler RA. et.al.[141] | Rats | Transient global ischemia | i.c.v. | Pre-24, 12, 6h | Single | 200pmol/rat |
| 2012 | Lazarovici P. et.al,[156] | Rats | tMCAO | i.v. | Post-2h | Single | 30ng/kg |
| 2012 | Nakamachi T. et.al.[152] | Mice | Transient global ischemia | i.c.v. | Post-surgery | Single | 1pmol/mice |
| 2014 | Hori M. et. al.[153] | Mice | pMCAO | i.c.v. | Post-surgery | Single | 1pmol/mice |
| 2014 | Lin C. et al.[93] | Rats | Transient global ischemia | i.p. | Post-4h | Single | 10μg/kg |
| 2015 | Brifault C. et.al.[154] | Mice | pMCAO | i.c.v. | Post-72h | Single | PACAP-producing-stem cell |
Abbreviations: PACAP pituitary adenylate cyclase-activating polypeptide; tMCAO transient middle cerebral carotid occlusion; pMCAO permeant middle cerebral carotid occlusion; i.c.v intracerebroventricular injection; i.v. intravenous injection; i.p. intraperitoneal injection