Table 1.
BDNF polymorphisms and their relationship with multiple diseases. Each polymorphism was looked up in SNPedia and verified in the reference.
| SNPs | Position in Chromosome | Nucleotide Change |
Protein effect | Related diseases |
|---|---|---|---|---|
| rs10767664 | 27.704.439 |
T/A |
Intron variant |
Asthma [6] Allergic Rhinitis [73] Obesity [67] |
| rs10835210 | 27.654.363 | C/A/G | Intron variant | Schizophrenia [105] |
| rs11030100 | 27.656.039 | C/T | 3'UTR variant | Asthma [104] |
| rs11030101 | 27.659.197 |
A/T |
5'UTR variant |
Depression Asthma [104] Bipolar disorder [74] |
| rs11030103 | 27.660.786 | A/G | Intron variant | Depression and Suicide [59] |
| rs11030104 | 27.662.970 | A/G | Intron variant | Panic attacks Bipolar disorder Alzheimer disease [50] |
| rs11030107 | 27.673.288 | A/G | Intron variant | Bipolar Disorder [83] |
| rs12273363 | 27.723.312 | T/C | Intron variant | Major Depressive Disorder[46] Bipolar disorder |
| rs12273539 | 27.661.764 | C/T | Intron variant | Depression and suicide |
| rs12291063 | 27.672.554 | T/C | Intron variant | Obesity [16] |
| rs13306221 | 27.701.142 | C/T | Intron variant | Alcohol dependency [100] Heroin dependency [52] |
| rs16917237 | 27.680.836 | G/T | Intron variant | Bipolar Disorder [102] Asthma |
| rs2030323 | 27.706.992 | A/C | Intron variant | Obesity [35] [36] |
| rs2030324 | 27.705.368 | A/G | Intron variant | Alzheimer Disease [26] Parkinson Disease [95] PTSD [41] |
| rs2049045 | 27.672.694 | G/A/C | Intron variant | Bipolar Disorder |
| rs2049046 | 27.702.228 | T/A | Intron variant | Obsesive Compulsive disorder |
| rs28722151 | 27.659.629 | C/G | 5´ UTR | Depression and suicide |
| rs41282918 | 27.657.233 | A/C | 3´ UTR | Depression and suicide |
| rs6265 | 27.658.369 | G/A |
Missense variant G196A Val 66 Met |
Major Depressive disorder Hypertension AD PD T2D Depression Asthma Allergic Rhinitis |
| rs7103411 | 27.678.578 | C/T | Intron variant | PTSD Epilepsy [41] |
| rs7103873 | 27.678.770 | G/A/C | Intron variant | Depression [65] |
| rs7127507 | 27.693.337 | T/C | Intron variant | Hippocampal Volume in cerebral injury [44] |
| rs8192466 | 27.658.560 | G/A/T | Missense variant Thr2 Ile |
Schizophrenia |
| rs962369 | 27.712.873 | T/C | Intron variant | Depression and suicide [72] |
| rs988748 | 27.703.198 | C/G | Intron variant | Depressive disorder Bipolar disorder [88] |