Table 3.
Main pharmacokinetic parameters of plasma in normal mice after intravenous injection of BA-LP and BA.
| Parameters | Units | BA-LP | BA |
|---|---|---|---|
| AUC0-t | mg/L∗min | 17536.084 ± 928.392 | 2712.911 ± 55.945 |
| AUC0-∞ | mg/L∗min | 19574.508 ± 840.058 | 2958.151 ± 49.156 |
| MRT0-t | min | 102.636 ± 1.749 | 17.354 ± 0.16 |
| MRT0-∞ | min | 172.950 ± 14.110 | 41.167 ± 3.073 |
| t 1/2 | min | 202.963 ± 18.291 | 127.18 ± 10.849 |
| V d | L/kg | 1.500 ± 0.168 | 6.209 ± 0.582 |
| CLz | L/min/kg | 0.005 | 0.0338 ± 0.0004 |
| C max | mg/L | 192.689 ± 9.210 | 102.165 ± 1.788 |
BA-LP and BA were administered by intravenous injection at 100 mg/kg, and data were expressed as mean ± SD (n = 5).