Table 4. Comparison of SARS-CoV-2 MA virus lung titers with either single hu-mAb or hu-mAb combination prophylaxis.
| Antibody ID | C121-LS | C135-LS | C144-LS | C135-LS+C121-LS | C135-LS+C144-LS | Isotype control | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose level (mg/kg) | 8 | 8 | 8 | 16 | 5.3 | 1.8 | 16 | 5.3 | 1.8 | 16 | |
| Number of animals | 10 | 9 | 10 | 15 | 9 | 10 | 15 | 10 | 10 | 14 | |
| Minimum (PFU/ml) | 1.5E+02 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 4.5E+01 | 3.3E+05 | |
| Maximum (PFU/ml) | 7.5E+03 | 3.5E+03 | 2.0E+03 | 4.5E+01 | 6.0E+02 | 4.5E+05 | 3.0E+02 | 4.5E+01 | 1.2E+05 | 4.5E+06 | |
| Range | 7.4E+03 | 3.5E+03 | 2.0E+03 | 0.0E+00 | 5.6E+02 | 4.5E+05 | 2.6E+02 | 0.0E+00 | 1.1E+05 | 4.2E+06 | |
| Geometric mean (PFU/ml) | 1.1E+03 | 3.3E+02 | 1.5E+02 | 4.5E+01 | 1.2E+02 | 9.3E+03 | 5.1E+01 | 4.5E+01 | 6.9E+03 | 1.2E+06 | |
| Geometric SD factor | 4.0 | 4.8 | 5.0 | 1.0 | 2.8 | 21.9 | 1.6 | 1.0 | 18.6 | 2.4 | |