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. 2020 Nov 19;218(3):e20201993. doi: 10.1084/jem.20201993

Table 4. Comparison of SARS-CoV-2 MA virus lung titers with either single hu-mAb or hu-mAb combination prophylaxis.

Antibody ID C121-LS C135-LS C144-LS C135-LS+C121-LS C135-LS+C144-LS Isotype control
Dose level (mg/kg) 8 8 8 16 5.3 1.8 16 5.3 1.8 16
Number of animals 10 9 10 15 9 10 15 10 10 14
Minimum (PFU/ml) 1.5E+02 4.5E+01 4.5E+01 4.5E+01 4.5E+01 4.5E+01 4.5E+01 4.5E+01 4.5E+01 3.3E+05
Maximum (PFU/ml) 7.5E+03 3.5E+03 2.0E+03 4.5E+01 6.0E+02 4.5E+05 3.0E+02 4.5E+01 1.2E+05 4.5E+06
Range 7.4E+03 3.5E+03 2.0E+03 0.0E+00 5.6E+02 4.5E+05 2.6E+02 0.0E+00 1.1E+05 4.2E+06
Geometric mean (PFU/ml) 1.1E+03 3.3E+02 1.5E+02 4.5E+01 1.2E+02 9.3E+03 5.1E+01 4.5E+01 6.9E+03 1.2E+06
Geometric SD factor 4.0 4.8 5.0 1.0 2.8 21.9 1.6 1.0 18.6 2.4