Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 17;11(11):988. doi: 10.1038/s41419-020-03194-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — The SW480 cells were treated with two concentrations of TalaA for 12 h. A Volcano plot showing the differences in RNA expression after 5.0 μM TalaA treatment. VPL means low concentration (5.0 μM) TalaA treatment; VPC means no chemical treatment (DMSO Control). B The volcano plot showing the differences in RNA expression after 10.0 μM TalaA treatment. VPH means high concentration (10.0 μM) TalaA treatment; VPC means no chemical treatment (DMSO control). C Through KEGG-enrichment analysis, it was found that the ferroptosis pathway molecules were up-regulated by 5.0 μM TalaA. D KEGG-enrichment analysis showed that the ferroptosis pathway molecules were up-regulated by 10.0 μM TalaA. E The heatmap data showed 5.0 μM TalaA resulted in gene expression alteration of ferroptosis-correlated molecules including FTL, SAT2, ALOXE3, GSS, ALOX12, HMOX1, ACSL5, and so on. F The heatmap data showed 10.0 μM TalaA resulted in gene expression alteration of ferroptosis-correlated molecules including FTL, SLC7A11, HMOX1, ALOXE3, SAT1, SAT2, GSS, ACSL5, ALXO12, PCBP1, MAP1LC3P, and so on.