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. 2020 Nov 17;11:5848. doi: 10.1038/s41467-020-19563-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Scatterplot showing high correlation between predicted average percent viability and experimentally observed average percent viability for each drug combination in NCI-ALMANAC. Predictions were made using monotherapy data from the dataset. The green line is a reference diagonal with slope = 1 and intercept = 0. Note that predictions were only made for the maximum concentration tested for each drug. b Density plot showing that the absolute values of the differences between the predicted percent viabilities and the observed percent viabilities for each drug combination are generally below 10%, with >50% of drug combinations having an absolute prediction error below 5%. The red line marks a difference of ±10% viability between predicted and observed values. c Density plot showing that the differences between the predicted percent viabilities and the observed percent viabilities for each drug combination have a slight tendency towards being positive—indicating that IDA-Combo underestimates efficacy more often than it overestimates efficacies. Source data are provided as a Source Data file.