Table 4.

Experimental T-cell MHC restriction immunodominant epitopes from Plasmodium falciparum that share homology with SARS-CoV-2 T-cell MHC epitopes

P. falciparum						SARS-CoV-2
ID	Sequence	Mapped start–end	Epitope antigen name	Epitope parent name	MHC allele	Sequence	Protein name	Mapped start–end	Identity
34480	KYKIAGGIAGGLALL	509–523	Sporozoite surface protein 2	TRAP	HLA-DRB1∗01:01, HLA-DRB1∗04:01, HLA-DRB1∗07:01, HLA-DRB1∗08:02, HLA-DRB1∗09:01, HLA-DRB1∗11:01, HLA-DRB1∗12:01, HLA-DRB1∗13:02, HLA-DRB5∗01:01	GDAALALLLL	N	215–224	40
34480	KYKIAGGIAGGLALL	509–523	Sporozoite surface protein 2	TRAP	HLA-DRB1∗01:01, HLA-DRB1∗04:01, HLA-DRB1∗07:01, HLA-DRB1∗08:02, HLA-DRB1∗09:01, HLA-DRB1∗11:01, HLA-DRB1∗12:01, HLA-DRB1∗13:02, HLA-DRB5∗01:01	LALLLLDRL	N	219–227	44.4
20762	GLALLACAGL	504–513	TRAP precursor	TRAP	HLA-A∗02:01	GDAALALLLL	N	215–224	40
20762	GLALLACAGL	504–513	TRAP precursor	TRAP	HLA-A∗02:01	LALLLLDRL	N	219–227	44.4
35388	LEDIINLSKKKKKSINDTSF	2557–2576	Putative erythrocyte binding protein EBL-1	EBL-140	HLA-DRB1∗11:01	WLMWLIINL	ORF1ab	2292–2300	44.4
32526	KNKEKALII	109–117	Sporozoite surface protein 2	TRAP	HLA-B8	SMWALIISV	ORF1ab	3661–3669	44.4
2632	ALIIIRSLL	114–122	TRAP precursor	TRAP	HLA-A∗02:01

HLA, human leukocyte antigen; MHC, major histocompatibility complex; ORF, open reading frame; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TRAP, thrombospondin-related anonymous protein.