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Trial diagram. Women were enrolled at 16 to 28 weeks gestation. PK sampling began at 20 weeks gestation and continued until delivery. iPK (box) indicates intensive PK sampling at 28 weeks gestation. The asterisk indicates two of the women included in the postpartum sampling group received SP during pregnancy. The number of women enrolled and randomized reported here reflects only those who went on to initiate study drug. q4wk, doses given every 4 weeks; q8wk, doses given every 8 weeks.
