TABLE 3.
PK/PD objectives and probability of target attainment for various cloxacillin dosage regimens simulated in 2,000 patientsa
| Cloxacillin daily dosage (mg), interval | Infusion time (h) | Median fT>MIC (95% CI)b | PTAc for: |
|
|---|---|---|---|---|
| 50% fT>MIC | 100% fT>MIC | |||
| 2,000, q6h | 1 | 0.50 (0.39–0.73) | 0.50 | 0 |
| 2,000, q6h | 2 | 0.59 (0.49–0.82) | 0.96 | 0 |
| 2,000, q6h | 3 | 0.70 (0.61–0.93) | 1 | 0 |
| 2,000, q6h | 4 | 0.83 (0.73–1) | 1 | 0.09 |
| 3,000, q6h | 1 | 0.60 (0.45–0.84) | 0.88 | 0 |
| 3,000, q6h | 2 | 0.69 (0.56–0.93) | 1 | 0 |
| 3,000, q6h | 3 | 0.80 (0.68–1) | 1 | 0.07 |
| 3,000, q6h | 4 | 0.92 (0.81–1) | 1 | 0.29 |
| 2,000, q4h | 1 | 0.78 (0.60–1) | 1 | 0.15 |
| 2,000, q4h | 2 | 0.94 (0.76–1) | 1 | 0.38 |
| 6,000 | Continuous | 1 | 1 | 1 |
| 8,000 | Continuous | 1 | 1 | 1 |
| 10,000 | Continuous | 1 | 1 | 1 |
| 12,000 | Continuous | 1 | 1 | 1 |
a
The results are given for an MIC of 0.5 mg/liter and a BSA of 1.75 m2. q6h, every 6 h; q4h, every 4 h.
b
95% CI, 95% confidence interval.
c
PTA, probability of target attainment.