TABLE 1.
Associations between exposure to IPTp and transporter gene polymorphisms
| Locus | Drug exposure | Mutation prevalence (no. mixed and mutant/total no. samples [%]) | Prevalence ratioa (95% CI) | P value | Prevalence ratiob (95% CI) | P value |
|---|---|---|---|---|---|---|
| pfmdr1N86Y | Before IPTp | 12/307 (3.9) | Reference | |||
| SP | 7/113 (6.2) | 1.58 (0.64–3.93) | 0.32 | Reference | ||
| DP | 15/74 (20.3) | 5.19 (2.53–10.6) | <0.001 | 3.27 (1.40–7.64) | 0.005 | |
| pfmdr1Y184F | Before IPTp | 158/298 (53.0) | Reference | |||
| SP | 52/116 (44.8) | 0.85 (0.67–1.06) | 0.15 | Reference | ||
| DP | 54/74 (73.0) | 1.38 (1.16–1.64) | <0.001 | 1.63 (1.27–2.08) | 0.0002 | |
| pfmdr1D1246Y | Before IPTp | 22/299 (7.4) | Reference | |||
| SP | 8/109 (7.3) | 0.99 (0.46–2.18) | 0.99 | Reference | ||
| DP | 5/74 (6.8) | 0.92 (0.36–2.35) | 0.78 | 0.92 (0.31–2.70) | 0.88 | |
| pfcrtK76T | Before IPTp | 72/300 (24.0) | Reference | |||
| SP | 25/96 (26.0) | 1.09 (0.73–1.61) | 0.68 | Reference | ||
| DP | 26/56 (46.4) | 1.93 (1.37–2.74) | <0.001 | 1.78 (1.15–2.77) | 0.01 |
a
Reference group is Before IPTp.
b
Reference group is SP.