TABLE 1.
MIC values of different antimicrobials against three MRSA strains, assessed individually and in combination with bacteriocins
| Antimicrobial | MIC (μg/ml) for strain: |
|||||||
|---|---|---|---|---|---|---|---|---|
| MRSA ATCC 33591-lux |
MRSA USA-300 |
MRSA 43484 |
All three strainsa
|
|||||
| Single antimicrobial | Combined with GarKS (antibiotic/GarKS) | Single antimicrobial | Combined with GarKS (antibiotic/GarKS) | Single antimicrobial | Combined with GarKS (antibiotic/GarKS) | Single antimicrobial | Combined with GarKS (antibiotic/GarKS) | |
| GarKS | 32 | 32 | 32 | 32 | ||||
| MP1 | 2.5 | 0.16/8 | 2.5 | 0.16/8 | 2.5 | 0.16/8 | 2.5 | 0.16/8 |
| Amp | >2,500 | 16/8 | >2,500 | 16/8 | >2,500 | 16/8 | >2,500 | 16/8 |
| PenG | >2,500 | 16/8 | >2,500 | 16/8 | >2,500 | 16/8 | >2,500 | 16/8 |
| Kan | >125 | 32/32 | >125 | 32/32 | >125 | 32/32 | >125 | 32/32 |
| Ery | >250 | 62/32 | 31 | 16/8 | 62 | 32/16 | 31 to >2,500 | 16 to 62/8 to 32 |
| Str | >2,500 | 32/8 | 62 | 32/16 | 62 | 32/16 | 62 to >2,500 | 32/8 to 16 |
| Tet | 150 | 38/32 | 1.2 | 0.6/16 | 1.2 | 0.6/16 | 1.2 to 150 | 0.6 to 37/16 to 32 |
| Cam | 125 | 32/32 | 125 | 64/32 | 16 | 64/32 | 16 to 125 | 32 to 64/8 to 32 |
| Combined with MP1 (antibiotic/MP1) | Combined with MP1 (antibiotic/MP1) | Combined with MP1 (antibiotic/MP1) | Combined with MP1 (antibiotic/MP1) | |||||
| PenG | 16/0.16 | 32/0.3 | 32/0.3 | 16 to 32/0.16 to 0.3 | ||||
| Combined with GarKS and MP1 (antibiotic/GarKS/MP1) | Combined with GarKS and MP1 (antibiotic/GarKS/MP1) | Combined with GarKS and MP1 (antibiotic/GarKS/MP1) | Combined with GarKS and MP1 (antibiotic/GarKS/MP1) | |||||
| PenG | 8/4/0.08 | 8/4/0.08 | 8/4/0.08 | 8/4/0.08 | ||||
a
Summary of the MIC values against all three strains.