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. 2020 Nov 17;64(12):e00654-20. doi: 10.1128/AAC.00654-20

FIG 1.

FIG 1

Structures and in vitro biological activities of selected dengue antiviral compounds. (A) Structures and in vitro biological profile of NITD-008 (1), R-1479 (2), and balapiravir (3). (B) Structures and in vitro biological profile of PSI-352938 (4), PSI-353661 (5), and their corresponding triphosphate 6 and nucleoside 7 metabolites. (C) Synthesis of cyclic phosphoramidate prodrugs of 6-O-alkyl-2′-deoxy-2′-fluoro-2′-C-methylguanosine. Reactions conditions are as follows: (i) t-BuMgCl in tetrahydrofuran; (ii) t-BuOK in DMSO; (iii) separation by preparative reverse-phase HPLC.