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Pharmacokinetic profiles of the intact prodrug (A), major metabolite nucleoside 7 in plasma (B), and triphosphate metabolite 6 in PBMCs (C) upon single rising doses of compound 17 in Beagle dogs. Error bars represent standard deviations (n = 3 dogs). The triphosphate concentration in PBMCs was determined only from the 10- and 30-mg/kg groups. At 10 mg/kg, the PBMC triphosphate level exceeded TP50.
