. 2020 Nov 17;64(12):e00654-20. doi: 10.1128/AAC.00654-20

TABLE 3.

In vitro activities and cytotoxicities of compound 17 across multiple serotypes and cell lines

Cell type	Assay type	Parameter	Activity (μM)
PBMC	DENV-1 (48 h)	EC₅₀	0.18 ± 0.06
	DENV-2 (48 h)	EC₅₀	0.23 ± 0.04
	DENV-3 (48 h)	EC₅₀	0.36 ± 0.33
	DENV-4 (48 h)	EC₅₀	0.37 ± 0.14
THP-1	DENV-2	EC₅₀	0.46 ± 0.20
KU812	DENV-2 high-content imaging	EC₅₀	1.41
K562	DENV-2	EC₅₀	2.79 ± 0.22
	Cytotoxicity	CC₅₀	>100
293T	DENV-2	EC₅₀	3.40
Huh-7	DENV-2 replicon expressing luciferase	EC₅₀	1.73 ± 1.06
HepG2	Cytotoxicity	CC₅₀	>100
MT-4	Cytotoxicity	CC₅₀	>100