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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Pharmacol Res. 2020 Sep 13;160:105190. doi: 10.1016/j.phrs.2020.105190

Figure 4. Role of prokineticin (PROK) signaling in development and injury of brain and heart.

Figure 4.

. Prokineticin receptors (mostly PKR1) signaling drives neurogenesis and cardiogenesis during development, and promotes survival signaling against heart and brain injuries. Prokineticin signaling may represent a common mechanism in neuroprotection and cardioprotection. Application of integrative medicine in neuro-cardiology will provide future therapeutic approach to treat chronic neurodegenerative and cardiovascular disorders.