. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Pharmacol Res. 2020 Sep 13;160:105190. doi: 10.1016/j.phrs.2020.105190

Table 3.

Altered expression of the prokineticin axes in neuronal and cardiovascular diseases

Diseases	Mutated/Altered Expression
Kallmann syndrome, idiopathic hypogonadotropic hypogonadism	PKR2, PROK2 [133]
Hirschsprung disease	PROK1, PROK2, PKR1, PKR2 [88]
Neuroblastoma progression	PROK1, PROK2, PKR1, PKR2 [134]
Parkinson’s disease	PROK2 [111]
Circadian Rhythm / sleep and Mood disorders	PROK2, PKR2 [135] [82, 125]
Autoimmune demyelination/Multiple sclerosis	PROK2[135]
Heart failure	PKR1, PROK2 [38]
Abdominal aortic aneurysm	PROK2 [91]
Metabolic diseases (Obesity and diabetes)	PROK2 [100]