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. Author manuscript; available in PMC: 2021 Nov 17.
Published in final edited form as: Acc Chem Res. 2020 Nov 2;53(11):2587–2599. doi: 10.1021/acs.accounts.0c00569

Table 1.

PK properties of 1, 16, 26and 32.a

Parameter vancomycin (1) CBP-vancomycin (16) C1-CBP-vancomycin (26) G3-CBP-vancomycin (32)
300 mg/kg 10 mg/kg 75 mg/kg 10 mg/kg 50 mg/kg 10 mg/kg 50 mg/kg 10 mg/kg
Cmax (μg/mL) 1665 62.8 125 65.0 58.9 14.1 152 35.9
tmax (h) 0.083 0.083 0.25 0.083 0.25 0.50 0.28 0.14
AUC (μg-h/mL) 935 21.8 575 135 430 81.1 312 66.0
Vd (L/kg) 0.62 0.34 1.24 1.28 1.04 1.25 0.35 0.41
CL (L/h/kg) 0.32 0.46 0.13 0.074 0.12 0.12 0.09 0.09
t1/2 (h) 1.35 0.52 6.6 12.0 6.2 7.0 4.4 4.3
a

Compounds administered iv @ MTD and 10 mg/kg in mice (n = 3/time point, measured at 0.083, 0.25, 0.5, 1, 2, 4, 6, 8 and 24 h).