Appendix Table 4.
Sensitivity Analysis of Overall PrEP Payments Using Crude, Single, and Multiple Imputation From Prescriptions With Complete Payment Data, 2014-2018
| Variable | 2014 | 2015 | 2016 | 2017 | 2018 |
|---|---|---|---|---|---|
| IQVIA base data set | |||||
| IQVIA overall sample payments, $ | 113 239 331 | 373 870 150 | 562 251 605 | 942 316 930 | 1 460 054 998 |
| IQVIAsample completeness, % | 99.3 | 98.9 | 68.8 | 68.8 | 69.0 |
| Crude imputation, $ | |||||
| Using $1400 forall missing total payments | 114 009 378 | 377 549 677 | 786 751 965 | 1 295 615 937 | 1 985 126 445 |
| Using $2000 forall missing total payments | 114 339 398 | 379 126 617 | 882 966 405 | 1 447 029 797 | 2 210 157 065 |
| Single imputation, $* | |||||
| Overall payments | 113 858 036 | 377 720 405 | 796 480 451 | 1 337 044 949 | 2 084 113 989 |
| Multiple imputation, 50 times, $* | |||||
| Mean overall payment | 113 978 754 | 377 828 569 | 795 085 311 | 1 333 358 057 | 2 076 567 589 |
| SD | 4977 | 8879 | 91 936 | 126 549 | 161 857 |
| Median overall payment | 113 978 380 | 377 827 446 | 795 080 980 | 1 333 361 145 | 2 076 541 565 |
| Minimum overall payment | 113 965 462 | 377 814 539 | 794 927 253 | 1 333 034 461 | 2 076 154 738 |
| Maximum overall payment | 113 990 274 | 377 852 681 | 795 286 344 | 1 333 660 128 | 2 076 903 514 |
PrEP = preexposure prophylaxis.
*
Imputation model predictor variables: out-of-pocket payment amount, tablets dispensed, third-party payer type, pharmacy type, geographic region, patient sex, and year.