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Intravenous infusion of L-NMMA blocks IHE-induced pulmonary artery (PA) vasodilation in 7 healthy volunteers measured by MRI. Summary changes during isometric handgrip exercise (% CSA increase from baseline values) for placebo (saline infusion) and during L-NMMA infusion showing that L-NMMA significantly blunts the IHE-induced increase in PA area in response to IHE (p=0.001 response during placebo vs l-NMMA).
