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. Author manuscript; available in PMC: 2021 Dec 15.
Published in final edited form as: Biol Psychiatry. 2020 May 19;88(12):910–921. doi: 10.1016/j.biopsych.2020.05.011

Figure 2. MG depletion prevents dependence-induced escalation in alcohol intake.

Figure 2.

(a) Change in average weekly two bottle choice (2BC) ethanol (EtOH) intake (escalation) between week 4 and baseline. (b) Average weekly 2BC intake after each week of chronic intermittent ethanol (CIE) treatment. (c) Novelty-suppressed feeding test (NSFT) and latency to eat in the open field. (d) NSFT and latency to eat in the home cage. n=12 mice per group, except for the Control Diet/Non-Dep (non-dependent) group in the NSFT (n=9). Data are presented as mean±SEM values; # P<0.05, ## P<0.01, planned orthogonal contrasts.