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. 2020 Nov 5;8:590008. doi: 10.3389/fcell.2020.590008

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Copyright © 2020 Ge, Yang, Li, Wang, Lin, Feng, Chen, Jiang, Wang, Hu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Beneficial effects of NeuroD1-based gene therapy delivered at 10 days after ischemic stroke in monkey cortex. (A) Experimental design for NeuroD1 treatment at 10 days after ischemic stroke. (B) Representative images showing mCherry (red), NeuN (green) and NeuroD1 (white) expression pattern in non-stroke cortex (left column) or in ischemic cortex after virus infection (right 4 columns). NeuroD1-infected areas consistently showed higher neuronal density. Scar bars, 50 μm. (C) Representative images showing mCherry (red), MAP2 (green), and NeuroD1 (white) expression pattern in non-stroke cortex (left column) or in ischemic cortex after viral injection (right 4 columns). The neuronal dendritic marker MAP2 signal increased significantly in NeuroD1-infected areas, compared to the control mCherry-infected areas. Scar bars, 50 μm.