Fig. 5.

Tumour-infiltrating immune cells and angiogenesis in PitNETs. Microvessel density (MVD) and vascular architecture parameters in pituitary neuroendocrine tumours (PitNETs) with lower versus higher amounts of a FOXP3+ T cells, b CD4+ T cells and c B cells. The PitNET-infiltrating immune cell thresholds considered here were the same as those previously published in [9]. d Representative images of a tumour with lower versus a sample with higher amounts of FOXP3+ T, CD4+ T and B cells are shown (×20); scale bar: 100 µm. *p < 0.05, **p < 0.01, ***p < 0.001 (Mann–Whitney U test)