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. 2020 Nov 18;10:20032. doi: 10.1038/s41598-020-77014-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo electrophysiological study. (A) Summary of in vivo ventricular tachycardia (VT) inducibility. (B) Percentage of VT episodes by pacing protocols. The number and percentage of pacing-induced VT were shown in the middle of each bar. Pretreatment of ranolazine significantly reduced the inducibility ratio of VT episodes by both burst pacing and extrastimulus pacing protocols in db/db and db/+ groups. (C) Distribution of the severity of VT, plotted as the number of beats of VT. The number and percentage of VT episodes were shown on the top of each bar. The db/db C group had higher percentage of long VT (> 30 beats) than other groups (P = 0.031). (D) A representative example of pseudo-electrocardiogram showing extrastimulus pacing-induced VT in a db/db C mouse heart.