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. 2020 Nov 18;11:5872. doi: 10.1038/s41467-020-19760-3

Fig. 5. Deletion of KLF2 confined to peripheral myeloid cells contributes to metabolic disease.

Fig. 5

a Schematic depiction of bone marrow transplant protocol and resultant chimeras created. b Chimeras with preserved WT microglia but K2KO hematopoietic myeloid cells (KO>WT) demonstrate elevated body weight gain on 4 weeks HFD, WT>WT n = 9, WT>KO n = 10, KO>WT n = 13, p = 0.0002 (1 week), <0.0001 (2 weeks), 0.0020 (3 weeks), 0.0028 (4 weeks) comparing WT>WT to KO>WT. c Chimeras with preserved KO microglia but WT hematopoietic myeloid cells (WT>KO) demonstrate elevated food intake across one month HFD, WT>WT n = 4, WT>KO n = 7, KO>WT n = 5, p = 0.0251. (d) KO > WT mice have slightly worse glucose intolerance on GTT, n = 5 (p = 0.0202 at 90 min, 0.0109 at 120 min) and (e) worse insulin sensitivity on ITT, n = 5, p = 0.0111 (15 min) and 0.0177 (120 min) by unpaired, two-tailed Student’s t-test, comparisons marked or indicated in figure. Error bars represent SEM. n represents biologically independent mice throughout entire figure. Source data are provided as a Source Data file.