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. 2020 Nov 18;10:20028. doi: 10.1038/s41598-020-77034-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of the β-tricarbonyl moiety compound on LPS-induced changes in dendritic spine density. Crl:CD1 mice were orally administered with 0, 1, or 3 mg/kg of AHC for 3 days, and intracerebroventricularly injected with 10 μg of LPS. At 3 days after LPS treatment, the brains were subjected to Golgi staining. (A) and (C) Representative images of Golgi staining in CA1 of hippocampus and locus coeruleus (LC), respectively. (B) and (D) Number of dendritic spines per 10 μm in CA1 (B) and LC (D). Data are presented as mean ± standard error (7 mice per group). The p values shown were calculated by one-way analysis of variance followed by the Tukey–Kramer test. *p < 0.05. AHC, 2-acetyl-3-hydroxy-2-cyclopenten-1-one; LPS, lipopolysaccharide.