Table 1.

Genes involved in lipid metabolism that are downregulated in the substantia nigra pars compacta of PD patients compared with control subjects.

Pathway	Human genes	Adjusted P-value
Phospholipid metabolism	ARF3, ASAH1, CERS6, CERK, PITPNB, PIK3R3, OCRL, MTMR4, PLD3, AGPAT4, INPP4A, PTDSS1, COL4A3BP, STS, SYNJ1, VAPB, OSBP, PI4KA, PIP5K1B, GPD1L, PI4K2A, CDS2	0.0003
Lipid and lipoprotein metabolism	ARF3, IDI1, ASAH1, ALAS1, CERK, PITPNB, PIK3R3, HMGCR, MTMR4, PLD3, AGPAT4, PTDSS1, COL4A3BP, STS, OXCT1, OSBP, PIP5K1B, PRKACB, CERS6, HMGCS1, SRD5A1, OCRL, MED7, INPP4A, ACLY, SYNJ1, VAPB, AGPS, PI4KA, GPD1L, PI4K2A, CDS2	0.0180
Sphingolipid metabolism	COL4A3BP, ASAH1, STS, CERS6, CERK, VAPB, OSBP, B4GALT6	0.0488