Table 1.
Variable | PartI | P value | PartII | P value | ||
---|---|---|---|---|---|---|
Normal responders | Hyper responders | Normal responders | Hyper responders | |||
N | 1527 | 1513 | 935 | 937 | ||
Female age | 29.32 ± 3.71 | 29.00 ± 3.69 | 0.0087* | 29.34 ± 3.65 | 29.08 ± 3.69 | 0.0974 |
Male age | 30.59 ± 5.03 | 30.09 ± 4.73 | 0.006* | 30.57 ± 4.92 | 30.12 ± 4.48 | 0.0682 |
Duration of infertility (years) | 3.62 ± 2.52 | 3.58 ± 2.47 | 0.9813 | 3.58 ± 2.47 | 3.58 ± 2.55 | 0.9647 |
Body mass index (kg/m2) | 22.54 ± 2.65 | 22.80 ± 2.56 | 0.0036* | 22.67 ± 2.62 | 22.97 ± 2.59 | 0.0124* |
Antral follicle count (n.) | 15.12 ± 5.33 | 16.81 ± 5.43 | <0.0001* | 15.43 ± 5.43 | 16.97 ± 5.59 | <0.0001* |
Infertility factors | ||||||
Secondary infertility | 631 (41.32) | 650 (42.96) | 0.36851 | 382 (40.86) | 390 (41.62) | 0.7362 |
Primary infertility | 895 (58.61) | 863 (57.04) | 553 (59.14) | 547 (58.38) | ||
Treatment | ||||||
ICSI | 348 (22.79) | 388 (25.64) | 0.06619 | 193 (20.64) | 222 (23.69) | 0.11208 |
IVF | 1179 (77.21) | 1125 (74.36) | 742 (79.36) | 715 (76.31) | ||
Total Gonadotrophin dose (IU) | 2141.97 ± 683.31 | 2058.87 ± 649.98 | 0.0005* | 2159.19 ± 677.14 | 2044.97 ± 645.96 | 0.0001* |
Gonadotrophin duration (d) | 13.56 ± 2.04 | 13.92 ± 1.97 | <0.0001* | 13.53 ± 2.02 | 13.87 ± 1.93 | <0.0001* |
Total oocytes obtained (n.) | 11.17 ± 2.85 | 21.46 ± 5.13 | <0.0001* | 11.17 ± 2.86 | 21.45 ± 5.08 | <0.0001* |
No. of 2PN oocytes | 6.87 ± 3.03 | 12.66 ± 5.00 | <0.0001* | 6.86 ± 3.05 | 12.43 ± 4.78 | <0.0001* |
No. of MII oocytes | 8.43 ± 3.73 | 16.26 ± 6.38 | <0.0001* | 8.92 ± 3.28 | 16.89 ± 5.62 | <0.0001* |
No. of 2PN cleavage embryos | 8.15 ± 3.26 | 15.11 ± 5.82 | <0.0001* | 8.26 ± 3.26 | 15.06 ± 5.80 | <0.0001* |
Outcomes | <0.0001* | <0.0001* | ||||
Whole embryo freezing | 146 (9.57) | 602 (39.79) | 87 (9.32) | 346 (36.93) | ||
No cleavage | 4 (0.26) | 1 (0.07) | 3 (0.32) | 1 (0.11) | ||
Cancellation | 1 (0.07) | 0 | 0 | 0 | ||
No insemination | 12 (0.78) | 3 (0.20) | 8 (0.85) | 3 (0.32) | ||
No transfer | 12 (0.79) | 26 (1.72) | 7 (0.75) | 10 (1.07) | ||
No transferred embryo | 50 (3.28) | 15 (0.99) | 30 (3.22) | 8 (0.85) | ||
Transfer | 1296 (84.98) | 864 (57.11) | 796 (85.32) | 568 (60.62) | ||
Abnormal fertilization | 4 (0.26) | 2 (0.13) | 2 (0.21) | 1 (0.11) | ||
Missing | 2 | 2 |
*P < 0.05.