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. 2020 Nov 5;11:536100. doi: 10.3389/fendo.2020.536100

Table 1.

Characteristics and outcomes of patients during August 2015 to December 2017.

Variable PartI P value PartII P value
Normal responders Hyper responders Normal responders Hyper responders
N 1527 1513 935 937
Female age 29.32 ± 3.71 29.00 ± 3.69 0.0087* 29.34 ± 3.65 29.08 ± 3.69 0.0974
Male age 30.59 ± 5.03 30.09 ± 4.73 0.006* 30.57 ± 4.92 30.12 ± 4.48 0.0682
Duration of infertility (years) 3.62 ± 2.52 3.58 ± 2.47 0.9813 3.58 ± 2.47 3.58 ± 2.55 0.9647
Body mass index (kg/m2) 22.54 ± 2.65 22.80 ± 2.56 0.0036* 22.67 ± 2.62 22.97 ± 2.59 0.0124*
Antral follicle count (n.) 15.12 ± 5.33 16.81 ± 5.43 <0.0001* 15.43 ± 5.43 16.97 ± 5.59 <0.0001*
Infertility factors
Secondary infertility 631 (41.32) 650 (42.96) 0.36851 382 (40.86) 390 (41.62) 0.7362
Primary infertility 895 (58.61) 863 (57.04) 553 (59.14) 547 (58.38)
Treatment
ICSI 348 (22.79) 388 (25.64) 0.06619 193 (20.64) 222 (23.69) 0.11208
IVF 1179 (77.21) 1125 (74.36) 742 (79.36) 715 (76.31)
Total Gonadotrophin dose (IU) 2141.97 ± 683.31 2058.87 ± 649.98 0.0005* 2159.19 ± 677.14 2044.97 ± 645.96 0.0001*
Gonadotrophin duration (d) 13.56 ± 2.04 13.92 ± 1.97 <0.0001* 13.53 ± 2.02 13.87 ± 1.93 <0.0001*
Total oocytes obtained (n.) 11.17 ± 2.85 21.46 ± 5.13 <0.0001* 11.17 ± 2.86 21.45 ± 5.08 <0.0001*
No. of 2PN oocytes 6.87 ± 3.03 12.66 ± 5.00 <0.0001* 6.86 ± 3.05 12.43 ± 4.78 <0.0001*
No. of MII oocytes 8.43 ± 3.73 16.26 ± 6.38 <0.0001* 8.92 ± 3.28 16.89 ± 5.62 <0.0001*
No. of 2PN cleavage embryos 8.15 ± 3.26 15.11 ± 5.82 <0.0001* 8.26 ± 3.26 15.06 ± 5.80 <0.0001*
Outcomes <0.0001* <0.0001*
Whole embryo freezing 146 (9.57) 602 (39.79) 87 (9.32) 346 (36.93)
No cleavage 4 (0.26) 1 (0.07) 3 (0.32) 1 (0.11)
Cancellation 1 (0.07) 0 0 0
   No insemination 12 (0.78) 3 (0.20) 8 (0.85) 3 (0.32)
   No transfer 12 (0.79) 26 (1.72) 7 (0.75) 10 (1.07)
   No transferred embryo 50 (3.28) 15 (0.99) 30 (3.22) 8 (0.85)
Transfer 1296 (84.98) 864 (57.11) 796 (85.32) 568 (60.62)
Abnormal fertilization 4 (0.26) 2 (0.13) 2 (0.21) 1 (0.11)
Missing 2 2

*P < 0.05.