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. 2020 Nov 18;10:20059. doi: 10.1038/s41598-020-77036-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmaps of mRNA expression of 730 immune-related genes in 66 tumor samples from 33 patients. Patients were divided into two groups of patients: those with CD8 R/I < 1 (group1) and those with CD8 R/I > 1 (group2). A heatmap was made using the R/I ratio of each gene. Y-axis was clustered into two groups (groups 1 and 2), and x-axis was clustered hierarchically. A part of the heatmap showed a noticeable pattern between groups 1 and 2.